Archive for January, 2009

Yahoo’s Briefcase to Close March 30

Saturday, January 31st, 2009

Yahoo’s Briefcase online storage service, which soldiered on for almost 10 years with a distinctly Web 1.0 capacity of 30MB, is finally being shut down.

Users of the free service, which lets people upload files as big as 5MB and organize them in folders, are being greeted by a message that says they have to download or delete their files by March 30. After that, the accounts will be closed and files deleted.

Yahoo is discontinuing Briefcase because users outgrew it, Yahoo said in a statement. Other services, such as Yahoo Mail and Flickr, offer far greater storage capacity, and the use of Briefcase has fallen in recent years, the company said. The move will help it to focus on services that are more widely used, according to Yahoo.

As it battles Google and Microsoft in the search arena and struggles to bring in more revenue from its array of other services, Yahoo is being driven toward tighter focus. The company announced layoffs last year and has seen its stock price plunge since a proposed acquisition by Microsoft fell apart in May 2008.

Time may have passed Briefcase by, but the idea of Internet-based file storage is alive and well. Microsoft last year announced Live Mesh, a service now in beta testing that lets users store files online, keep them synchronized across mobile devices and PCs, and access them on the road. The free DropBox application offers similar capabilities. And Google is rumored to be near introducing an online storage service called GDrive.

Roche goes hostile, cuts Genentech bid to $42 billion

Saturday, January 31st, 2009

Roche cut its offer for Genentech Inc, launching a hostile bid which dashed investor hopes of a sweetened offer for the 44 percent of the U.S. biotech group its does not already own.

Roche Holding AG’s new and lower offer for the outstanding shares, pitched directly to shareholders, was a surprise and reflected tougher financing conditions and a drop in Genentech Inc shares, analysts said on Friday.

“We are confident that we will have the financing available when the money is needed,” Roche Chairman Franz Humer told reporters.

Roche is now making a public tender offer at $86.50 per share in cash, valuing the deal at $42 billion, replacing its initial bid that totaled $44 billion.

Roche stock rose 1.5 percent to 162.70 Swiss francs by 1039 GMT as investors welcomed the slightly lower price. Genentech shares in Frankfurt rose 1.9 percent to 65.51 euros ($85.69).

The move comes just days after the world’s biggest drugmaker Pfizer Inc agreed to buy rival Wyeth for $68 billion, backed by a new $22.5 billion loan, indicating debt markets for cash rich pharmaceutical makers are far from dead.

Roche had initially aimed to acquire the remaining shares through a negotiated settlement — an offer rejected by Genentech — and decided to appeal directly to shareholders after further talks failed to reach an agreement, Humer said.

“The plan is to use as financing partly our own funds, and then obviously bonds and then commercial paper and traditional bank financing. We will start by going to the bond market first,” he said.

BIG-SELLING CANCER DRUGS

Buying Genentech would give Roche control of all revenues for blockbuster cancer drugs Avastin and Herceptin, as well as absorbing an attractive portfolio of new medicines, and reflects Big Pharma’s rush to acquire biotech assets to fill sparse new product pipelines.

Roche appeared to be raising the pressure on Genentech, which analysts said could be trying to delay the process until key clinical data on its blockbuster cancer drug Avastin due in April — when positive results could drive up the company’s value.

“By reaching out directly to minority shareholders Roche will soon get an answer from the shareholders what they think is a fair offer,” said Andrew Weiss at Swiss bank Vontobel.

Helvea analyst Karl-Heinz Koch believed the offer should attract interest from Genentech shareholders, saying 80 percent ownership would be enough to integrate the U.S. company.

Koch said a deal at the new price could still be earnings accretive for Roche in 2010 and 2011, even at a debt financing cost of up to 8 to 9 percent.

But Andreas Theisen, analyst at WestLB, reckoned few Genentech shareholders will jump at the offer.

“We believe Roche aimed to stick to its take-out plans, but is also trying to get some extra time until maybe financing conditions improve,” Theisen said.

OPPORTUNITIES IN DOWNTURN

Roche made a fresh round of calls to banks after news of the Pfizer-Wyeth deal emerged, bankers close to the Genentech deal told Reuters this week.

Business leaders meeting in Davos, meanwhile, said they saw opportunities in the global downturn, though leverage is out and a hard-nosed focus on cost cutting is the order of the day.

Roche, which currently owns 56 percent of the Genentech outstanding shares and originally bid $89 per share, pitched its new offer at a premium of nearly 3 percent over the Genentech’s closing price of $84.09 on Thursday, compared with a premium of 29 percent for the Wyeth deal.

The Swiss company declined to give details of how its planned financing would break down.

After the initial announcement in July 2008, shares in Genentech rose to a high of $99.05, but later fell back below the offer price as the credit crisis bit, which gave Roche leeway to lower its bid.

Greenhill & Co is financial advisor to Roche and Davis Polk & Wardell is legal counsel for the tender offer, which Roche expects to commence the tender offer within approximately two weeks.

Recession rocks Hollywood’s showbiz papers

Friday, January 30th, 2009

For more than 75 years, Daily Variety and The Hollywood Reporter have battled to be the movie industry’s top newspaper, but recent layoffs due to the recession and competition from Internet blogs has Hollywood wondering if it will soon become a one paper town.

Publishers of the showbusiness newspapers say advertising has plunged, even during the current Oscar season when movie studios pay well to hype their films with cover page ads.

Moreover, the papers face increased competition from bloggers providing a daily diet of Hollywood news and gossip, such as Nikki Finke’s DeadlineHollywoodDaily.com, Tina Brown’s TheDailyBeast.com and David Poland’s MovieCityNews.com.

Daily Variety and The Hollywood Reporter continue to compete vigorously through tough economic times.

“I think it’s going to be a battle royale, and there may only be one a year from now,” said Jonathan Taplin, a professor at the Annenberg School for Communication at the University of Southern California.

On Monday, Daily Variety owner Reed Business Information, a unit of Reed Elsevier Plc, said the economic slump forced it to lay off some 30 workers at the paper and its sister publications.

Those sister papers include weekly Variety, which is the grand dame of showbiz reporting having started in 1905 and spawned Daily Variety in 1933. Last year, Reed put the publications on the sales block.

The Hollywood Reporter was founded in 1930 and is now owned by media research firm Nielsen Co., which provides marketing and other media business information, as well as TV ratings.

It has cut its staff to slightly less than 90, about half the level five years ago, said publisher Eric Mika.

THE SHOW’S NOT OVER, YET

Neil Stiles, publisher of the Variety Group, said he does not concern himself with his competitor or doomsday predictions for the newspapers. “I don’t give it any thought at all as to whether there will be one or two,” he said.

Still, without giving figures Stiles said awards season ads are “markedly down,” and he doubts his paper’s award ads will migrate to the Web because studios get more punch from print.

“It hangs around in an agent’s office, people see it,” Stiles said. “It’s very visible in a very tangible way. Online tends to be more of a question where someone would have to go online to find it.”

Mika also defended his paper saying, “I don’t think advertisers and readers want just a single point of view.”

Losing one of the historic papers, known for their own style of news jargon, would rip a hole in Hollywood culture. Reading the trades remains a daily ritual for studio executives, producers, writers, directors and actors.

Winking headlines like Daily Variety’s “Katz-and-Mouse Game Over,” describing the rift between Jeffrey Katzenberg and then-CEO of Walt Disney Co. Michael Eisner, speak volumes to Hollywood insiders.

But Taplin, among others, said the papers are rapidly becoming outmoded as readers go to blogs that provide an edgier version of film and TV news.

MovieCityNews editor Poland said he expects The Hollywood Reporter will become a Web-only news outlet, and Daily Variety will cut back to publishing twice weekly. Both have long histories, and can raise revenue online from their archives.

“It probably is part of the salvation of these titles in the long run, whoever owns them and whatever format they’re in,” he said.

In fact, during the holidays The Hollywood Reporter went to a Web-only version for 12 separate days. Still, it has not announced any plans to embrace the Web as a day-to-day model.

Oil edges up towards $42 after sharp fall

Wednesday, January 28th, 2009

Oil edged higher towards $42 a barrel on Wednesday as stock markets rallied and an industry report showed U.S. inventories rose less than expected.

An American Petroleum Institute (API) report on Tuesday showed crude inventories rose by a less than anticipated 800,000 barrels. Stock markets advanced after reassuring corporate results on Wall Street.

“The market is very much range trading. It got offered down yesterday with people maybe expecting awful statistics, but the APIs were not too bad,” said Christopher Bellew, broker at Bache Commodities.

U.S. crude rose 14 cents a barrel to $41.72 by 1047 GMT. Prices have rallied from below $33 on Jan. 20. London Brent climbed 71 cents to $44.44.

The slight rebound followed a 9 percent plunge on Tuesday after grim economic data from top energy consumer the United States stirred investor concerns about slowing demand.

The API has begun releasing its weekly inventory report on Tuesday afternoons, a day ahead of the U.S. government’s Energy Information Administration (EIA).

Analysts expect crude stocks to rise by 2.9 million barrels.

The global economic crisis has weakened crude demand, especially in developed economies, boosting inventories and knocking prices down from a record high of $147.27 a barrel hit in July.

Supply cuts by the Organization of the Petroleum Exporting Countries (OPEC) since the second half of last year have offered prices some support against weakening demand.

Besides the EIA report, traders were also watching for the result of a two-day Federal Reserve meeting due out later in the day.

Policymakers are expected to hold their target for official borrowing costs in a range of zero to 0.25 percent.

Sony launches ‘purse-sized’ laptop

Monday, January 26th, 2009

Tech-savvy girls won’t have to carry the load of laptop bags anymore, for Sony has launched an ultra-portable “netbook” computer that will fit in any aspiring career woman’s purse.

The Vaio P boasts most features found on a laptop, from a webcam and GPS to a built-in 3G modem, allowing users to go online by inserting a mobile phone sim card.

The new netbook is aimed at people who want to surf the Internet, edit documents and check their emails on the go.

In fact, its designers have claimed that it is the lightest eight-inch netbook in the world.

They said it does everything that equivalent models of bigger sizes would do.

And the reviewers said that its keyboard, unlike many other small laptops, is easy to use.

While a basic model is available at 849 pounds, a faster-operating netbook with more memory will cost 1,370 pounds.

However, Joshua Topolsky from the technology website Engadget is not quite sure if many consumers will pay the asking price.

“It simply costs more than other options. A cost which Sony want users to ‘aspire’ to pay. There are plenty of viable, less expensive options,” The Telegraph quoted him as saying.

Friday Night Lights Stays in Ratings Game

Monday, January 19th, 2009

Friday TV’s Big Mystery, Other Than How Did Battlestar Galactica Do? Did Friday Night Lights do what it was supposed to do in its return to NBC? And what did NBC exactly expect it to do? Keep people home on Friday night? Help kill time until Jay Leno arrives? Make the masses feel bad about not having DirecTV (where they could have watched the show’s third season this past fall)?

What FNL Did: It stayed in the game. It ran fourth in the 9 p.m. hour in viewers, but only finished about 300,000 viewers out of second place, per Nielsen estimates as reported by Mediaweek. In the 18-49 demo, it tied for second with ABC’s Supernanny.

What FNL Did to Make Brooke Shields Look Bad: Compared to last week’s Lipstick Jungle, FNL was up in viewers (4.6 million versus 4.1 million) and the demo (1.6 rating versus 1.4 million).

Friday TV’s Winners: Ghost Whisperer (10.5 million), Flashpoint (10.4 million) and Numb3rs (10.9 million), all on CBS.

The Beast Update: The Patrick Swayze series averaged 3.6 million viewers for back-to-back premiere episodes on Thursday night, TVWeek reported. Last week, that would have been enough to land the show in cable’s Top 30.

Yahoo names software exec Bartz as new CEO

Friday, January 16th, 2009

Yahoo Inc named Autodesk Inc Chairman Carol Bartz as CEO, but Wall Street questioned whether the software executive has the experience needed to turn around the Internet media company.

While Bartz is a Silicon Valley veteran with a reputation for being a tough but fair manager, shareholders of Yahoo had hoped for a chief executive with more deal-making credentials who could revive talks with Microsoft Corp.

Yahoo also said on Tuesday that President Sue Decker, one of the candidates to succeed Jerry Yang as CEO, will resign after a transitional period. Other names that had been mentioned in the press as possible contenders include News Corp Chief Operating Officer Peter Chernin and Arun Sarin, ex-CEO of Vodafone Group Plc.

“I think the market may be a little bit disappointed that Yahoo’s not going with someone who isn’t a little bit more savvy when it comes to technology and media,” said Todd Greenwald, an analyst at Signal Hill.

Shares of Yahoo fell 3.6 percent after news of Bartz’s hire was reported on the Wall Street Journal’s website, but the stock recovered to end the day down just 1 percent at $12.10 as analysts said the end of the two-month CEO search could help bring some stability to the company.

Yang, who co-founded Yahoo, agreed in November to step down as CEO, capping a tumultuous year in which he angered many shareholders by rejecting a $47.5 billion takeover bid from Microsoft only to see an alternative Web search advertising partnership with Google Inc fall apart under U.S. antitrust scrutiny.

Yahoo has struggled to maintain its hold on the Internet search advertising market against Google, and suffered a dizzying stock slide after rejecting Microsoft’s bid.

DEEP DIVE

Bartz, 60, was chairman, president and CEO of software company Autodesk for 14 years until she stepped down in April 2006. Under her tenure, Autodesk’s revenues rose to more than $1.5 billion from less than $300 million, and its share price increased nearly ten-fold, Yahoo said.

Autodesk said Bartz will remain executive chairman even after taking the Yahoo job. She has also held executive positions at Sun Microsystems Inc and is on the boards of Cisco Systems Inc and Intel Corp.

Bartz, on her first conference call as Yahoo’s CEO, sharply rejected the idea that running an online media company would be a tough task given that her executive experience has mostly been in the software and technology fields.

“I didn’t know CAD (computer-aided design) when I joined Autodesk, I didn’t know hardware when I joined Sun,” she said in response to an analyst’s question. “I am a technology person, I am a market-driven person, I love customers. So I suspect I have a little brainpower to learn what it takes to understand media.”

Bartz said she would “dive deep” into Yahoo in the next few weeks to learn more about its operations, and will look to Yang, the board and employees to “jump-start my education.”

Gartner analyst Allen Weiner said Bartz is known as a leader who could build consensus among different factions.

“That’s certainly something that Yahoo needs right now. They need that adult leader to bring that order to the company,” he said. “She’s not what you would call a dot-com or Web insider, but maybe that’s not what Yahoo needs right now.

Bill Coleman, CEO of software maker Cassatt, who has known Bartz since 1985, said she was “an extrovert who gets energy out of being involved, being where the action is.”

“She has the unique ability to be able to look you in the eye and tell you exactly what you are doing wrong — how you messed up — and you leave feeling that she has done you a favor,” said Coleman, who worked for Bartz at Sun Microsystems in the 1980s and recruited her to the board of BEA Systems when he was BEA’s chief executive.

Bartz holds a bachelors degree in Computer Science from the University of Wisconsin.

Handling the Legal Side of Your Accident

Friday, January 16th, 2009

If you are trying to get the compensation that you deserve after an auto accident, then you are going to have to go a few things. You will have to do a few things for yourself. The first thing could be adopting an attitude of cynicism toward the insurance company. After that, you just have to hire one of the qualified auto accident lawyers Los Angeles. They will be able to handle the insurance company and save you a lot of trouble later on in your case.

The cynicism can even be ignored if you hire a lawyer soon enough. The problem is that the insurance company will usually do everything that they can do to reduce your payout. They are not your friend. This means a lot of confusing paperwork and a lot of secretive efforts to record you discussing the case. Any wrong move could really hurt you down, the line. The best thing that you can do is ignore their efforts and refer them to your attorney. Don’t let them record you and just politely make official meetings with your lawyer.

Auto accident attorney Los Angeles will also make the rest of the case fairly easy. Most personal injury cases don’t go to court. The majority just end in a settlement that is agreeable to both parties. This is actually your ultimate goal, since the strain of a court trial shouldn’t be taken lightly. Having an attorney will do a lot to make them respect you and offer a reasonable settlement early.

Wall crumbling between televisions and computers

Wednesday, January 14th, 2009

The wall between televisions and computers is crumbling and Internet pioneer Yahoo! is swinging a virtual hammer.

Today, in rapid-fire succession, Sony, LG Electronics, Toshiba, Samsung and Vizio showed off attention-grabbing new flat-panel television models embedded with Yahoo! “TV Widget” software offering links to popular websites.

By day’s end, MySpace revealed that some new Toshiba televisions are being built with Yahoo! widgets, mini- applications, letting viewers access the popular online social networking website by clicking on remote controls.

“We’ve been cooking this up in the lab for three or four years,” Yahoo! spokesman Lucas Mast said as his team displayed Connected TV technology at a Digital Experience event on the eve of the Consumer Electronics Show in Las Vegas.

Yahoo! has built 20 widgets to link television viewers to Internet destinations including YouTube, Twitter, eBay, MySpace, Amazon, CBS, and The New York Times. Mast expects that number to grow to 50 by June.

A YouTube widget allows videos from the hot website to be streamed to television sets, while a MySpace widget allows members to watch TV while connecting with online profiles and friends.

“We’re giving our users an entirely new way to easily enjoy, share and access MySpace content through the new MySpace experience for TV,” said MySpace vice president of business development Jason Oberfest.

Yahoo! developed the technology in collaboration with computer chip making colossus Intel.

Cause of cartilage degeneration in osteoarthritis uncovered

Tuesday, January 13th, 2009

Scripps research scientists have made a breakthrough discovery by finding the underlying cause of progressive deterioration of the cartilage, which characterises osteoarthritis- loss of the protein HMGB2.

The researchers showed how the loss of HMGB2, found in the surface layer of joint cartilage, leads to degeneration of cartilage in people suffering affected by osteoarthritis.

“We have found the mechanism that begins to explain how and why aging leads to deterioration of articular cartilage. Our findings demonstrate a direct link between the loss of this protein and osteoarthritis,” said Scripps Research Professor Martin Lotz, M.D., a world-renowned arthritis researcher who led the study with Noboru Taniguchi, M.D., Ph.D., a senior research associate in his lab.

Typically, osteoarthritis begins with a disruption of the surface layer of cartilage, called the superficial zone, which triggers an irreversible process that eventually leads to the loss of underlying layers of cartilage until bone begins to grind painfully against bone.

Osteoarthritis most commonly affects the spine, temporomandibular joints, shoulders, hands, hips and knees.

“We knew that the first phase of osteoarthritis is the destruction of cartilage in the superficial zone. Now we know that before this layer is destroyed, there is loss of the critical DNA binding protein HMGB2 and that this loss is directly related to aging,” said Lotz.

It was found that the protein HMGB2 is uniquely expressed on the surface layer of cartilage in joints, where it supports the survival of chondrocytes, the cells that produce and maintain cartilage.

Aging is associated with the loss of HMGB2 and an accompanying reduction or total elimination of chondrocytes in the superficial zone.

In fact, the scientists provided further links between HMGB2 and osteoarthritis by genetically breeding HMGB2 deficient mice that had an earlier and more severe onset of osteoarthritis.

The findings provide a promising avenue to explore the development of new osteoarthritis treatment options.

“If small molecules can be found to prevent or stop the loss of HMGB2, or conversely, to stimulate the production of this protein, then it is possible that osteoarthritis may one day either be prevented or reversed,” said Lotz.

The finding may provide scientists with a clue about how they might be able to engineer the surface layer cartilage.

“As our population ages, osteoarthritis will become an ever-greater health issue. Everyone eventually gets osteoarthritis; even those people who are not functionally impaired by the disease are found to have cartilage damage. And it all starts with the loss of cells in the superficial layer. We now have a starting point for potential prevention, diagnosis, and treatment,” said Lotz.

The scientists describe their work in this week’’s Early Edition of the Proceedings of the National Academy of Sciences.